Yasmina Ait Omar is the central character, with the season focusing on ideas of faith and religion, being Muslim in Belgium, and the holy month of Ramadan.

The series diverged from the original SKAM storyline with a new character, Kato Fransen. The storyline deals with social media, racism, self-harm, drugs, and COVID-19.

Robbe IJzermans is the central character and the season focuses on his coming out as gay and his relationship with Sander, who struggles with bipolar disorder. It also deals with themes of sexual identity, homosexuality, and mental health.

Zoë Loockx is the central character and the season focuses on her relationship with Senne, a popular boy at school, and themes of friendship, self-image, and sexual abuse.

Jana Ackermans is the central character and the season focuses on her relationship with her boyfriend Jens as well as themes of loneliness, identity, and friendship.

The popular youth series “wtFOCK” is back after three seasons. The fourth part is called “wtFOCKdown” this time. The characters find themselves in full-on corona crisis and are staying inside. The series unexpectedly started on the 1st of April and the characters are in "lockdown" at home. 羞耻(比利时版）疫情特别篇在2020年4月1日愚人节回归，故事里的角色在新冠肺炎疫情的危机中被迫居家隔离，故事主要通过社交媒体的互动和视频对话的形式开展，所有的场景都是工作人员在家中进行拍摄和制作的。

The popular youth series “wtFOCK” is back after three seasons. The fourth part is called “wtFOCKdown” this time. The characters find themselves in full-on corona crisis and are staying inside. The series unexpectedly started on the 1st of April and the characters are in "lockdown" at home. 羞耻(比利时版）疫情特别篇在2020年4月1日愚人节回归，故事里的角色在新冠肺炎疫情的危机中被迫居家隔离，故事主要通过社交媒体的互动和视频对话的形式开展，所有的场景都是工作人员在家中进行拍摄和制作的。

The story of young teenagers and pupils in a high school in Antwerp, and their troubles, scandals and everyday life. Each season is told from a different person's point of view.