It's the year 2210 and the world has been wiped out by a virus let loose on mankind by an alien race that wants to take over. Before they can do so, they find that two humans have survived the virus, a man and a woman. The gluttonous leader Lord Gideon dispatches his army of inept alien ninjas to finish them off so they can claim earth all for their own.

Continuing after the first "Subspecies", a woman who has just become a vampire tries to escape the evil vampire, Radu, who seeks her as his love interest. But she has taken the vampire family's bloodstone, and now Radu must find her to get it back. While her sister comes to Romania to save her soul. It might be too late....