When a fearless enemy out for revenge unleashes a brutal and deadly new virus, BSAA captain Chris Redfield enlists the help of Agent Leon S. Kennedy and Professor Rebecca Chambers to bring down the death merchant and save New York City.

U.S. federal agent Leon S. Kennedy sneaks into the "East Slavic Republic" to verify rumors that Bio-Organic Weapons (BOWs) are being used in the country's civil war, which the U.S. and Russia are making preparations to jointly intervene in. Right after his infiltration, the U.S. government orders him to leave immediately. Determined to uncover the truth, Leon ignores the order and enters the battlefield to end the chain of tragedies caused by the BOWs.