Molly McKay is a profoundly autistic twenty-something woman who has lived in an institution from a young age following her parents' death in a car accident. When the institution must close due to budget cuts, Molly is left in the care of her neurotypical, older brother, Buck McKay, an advertising executive and perennial bachelor. Buck forces her to undergo an experimental medical treatment, with unexpectedly drastic results.

On a university scholarship, a good natured student from the midwest gets a crash course in city life while dealing with three evil roommates. He befriends a virtually homeless college student whom he falls for, but she's dating a nasty professor.