A portal transports Cpt. Artemis and an elite unit of soldiers to a strange world where powerful monsters rule with deadly ferocity. Faced with relentless danger, the team encounters a mysterious hunter who may be their only hope to find a way home.

Picking up immediately after the events in Resident Evil: Retribution, Alice is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began - The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.

In 2257, a taxi driver is unintentionally given the task of saving a young girl who is part of the key that will ensure the survival of humanity.