Black Jack Murphy is the brains in an outfit of outlaws who rob the bank at Tusca City. All goes to plan with the heist but once the loot is safely obtained Jack's men lose no time in trying to double cross him. Wily Jack manages to outfox them at first and gets away with the cash but they soon catch up with him again and not only make off with the money but leave him crippled and carrying multiple causes for wanting revenge. This need for amends possesses Jack with an all consuming passion and he sets out to get even with each of his unfaithful former compadres but has his particular sights set on Indian Joe and Sanchez who abused and killed his beloved sister.

Renzo Tramaglino and Lucia Mondella are two poor farmers who are in love, but they are hampered by the wickedness of the powerful Don Rodrigo, who secretly loves Lucia. The two run away from Lake Como where they live, and take refuge inland.