When a congressional aide is killed, a Washington, D.C. journalist starts investigating the case involving the Representative, his old college friend.

A Reno singer witnesses a mob murder and the cops stash her in a nunnery to protect her from the mob's hitmen. The mother superior does not trust her, and takes steps to limit her influence on the other nuns. Eventually the singer rescues the failing choir and begins helping with community projects, which gets her an interview on TV—and identification by the mob.

An award-winning cynical journalist, Lloyd Vogel, begrudgingly accepts an assignment to write an Esquire profile piece on the beloved television icon Fred Rogers. After his encounter with Rogers, Vogel's perspective on life is transformed.

A lonely boy befriends a stray dog who has a natural talent for basketball and together they experience the highs and lows of life as their friendship remains solid through a series of escapades.

Deloris Van Cartier is again asked to don the nun's habit to help a run-down Catholic school, presided over by Mother Superior. And if trying to reach out to a class full of uninterested students wasn't bad enough, the sisters discover that the school is due to be closed by the unscrupulous chief of a local authority.

In the near future, due to a breakthrough scientific discovery by Dr. Thomas Harbor, there is now definitive proof of an afterlife. While countless people have chosen suicide to reset their existence, others try to decide what it all means. Among them is Dr. Harbor's son Will, who has arrived at his father's isolated compound with a mysterious young woman named Isla. There, they discover the strange acolytes who help Dr. Harbor with his experiments.

Ed Hemsler spends his life preparing for a disaster that may never come. Ronnie Meisner spends her life shopping for things she may never use. In a small town somewhere in America, these two people will try to find love while trying not to get lost in each other’s stuff.