Space captain Harlock, the latest in a family of proud aerial warriors, begins his journey to free the oppressed Earth from the despotic Illumidas Command.

A simple diamond heist leads Lupin into the machinations of a bizarre cult based around the prophecies of Nostradamus. They kidnap Julia, the daughter of Douglas, a wealthy American who is seeking the presidency, along with Lupin's diamond. At stake is the lost book of prophecy Douglas holds in the vault at the top of his skyscraper.

Lupin squares off with two criminal families and Inspector Zenigata's new female patrol to track down a hoard of biblical-era treasure.