Hana is a normal high school student, unsatisfied in her daily life. One day she had a dream and met a 10-year-old girl living in Sengoku Era. The girl lives hard with poverty and misfortune in that world and the two are going to have a sisterhood friendship. When Hana wakes up, she is taken away by the government special agency and subject to severe scrutiny about her dream. There is something called Akashic Record and the destinies of all humans follow that record. And the future record of all mankind is gone in a month. The key to solving the problem is the girl who appeared in Hana's dream.

Fifty years of war between the Great Eastern Federation and Europa - now merged as Eurasia - have taken their toll on planet Earth. As a result of the use of biological, chemical and nuclear weapons, much of Earth has become uninhabitable and people have become prey to new diseases. Professor Azuma's "neo-cell" project, which is supposed to be the answer to mankind's hardships, becomes a nightmare come true when mutants spawned from the experiment escape and declare war on the human race. Azuma's son Tetsuya, who was killed during the previous war, is reborn into the cyborg Casshern as mankind's last hope against the new mutant threat. This live-action sci-fi movie based on a 1973 Japanese animé of the same name.