Two men who have been friends since childhood find themselves on opposite ends of the law.

When an American booze smuggler gets murdered in Prohibition-era Mexico, his widow, a nightclub singer, joins forces with her lover and a desperate loner to become rum-runners to the U.S.

Hapless driving instructor and former Gunnery Sergeant Rafferty, living in squalor near Hollywood, California, doesn't put up too much of a fight when two ladies hitch a ride and attempt to kidnap him in their attempt to get to New Orleans; while initially put off, Rafferty finds he's charmed by the kooky pair of misfits and the three of them drive to Las Vegas, Nevada and later Tucson, Arizona, where their bond eventually unravels.

R.P.M. stands for (political) revolutions per minute. Anthony Quinn plays a liberal college professor at a west coast college during the hedy days of campus activism in the late 1960s. Radical students take over the college, the president resigns, and Quinn's character, who has always been a champion of student activism, is appointed president. As the students continue to push the envelope of revolution, Quinn's character is faced with the challenge of restoring order or abetting the descent into anarchy.