During the mid-22nd century, a century before Captain Kirk's five-year mission, Jonathan Archer captains the United Earth ship Enterprise during the early years of Starfleet, leading up to the Earth-Romulan War and the formation of the Federation.

Pulled to the far side of the galaxy, where the Federation is 75 years away at maximum warp speed, a Starfleet ship must cooperate with Maquis rebels to find a way home.

At Deep Space Nine, a space station located next to a wormhole in the vicinity of the liberated planet of Bajor, Commander Sisko and crew welcome alien visitors, root out evildoers and solve all types of unexpected problems that come their way.