Maldestro agente di Pubblica Sicurezza aiuta avventuriera a fuggire dall'Italia, poi si mette alla sua ricerca per riportarla in carcere. In mano a Vanzina il “fenomeno” Abatantuono, prima maniera, riesce a essere un po' meno la macchietta di sé stesso, aiutato anche da una costruzione accurata.

A few days before Inspector Ambrosio's holiday, a bank robbery takes place opposite his house.

After their prison ship sinks in the Caribbean, a group of prisoners and a doctor wash ashore on a seemingly deserted island. They soon discover a strange couple, who invite them to stay at their house. While the prisoners plan an escape, the doctor does some investigating, and soon finds out just what the pair are really doing, and why the prisoners keep disappearing mysteriously.

A reporter and her cameraman connect a surviving Jonestown leader and a TV exec's missing son to a drug war where jungle installations are being massacred by an army of natives and a skilled white assassin.