During the Republican run of the 2008 Presidential election, candidate John McCain picks a relative unknown, Alaskan governor Sarah Palin, to be his running mate. As the campaign kicks into high gear, her lack of experience, in both political and media savvy, becomes a drain upon McCain and his strategists.

Awkward teenager Charlie Bartlett has trouble fitting in at a new high school. Charlie needs some friends fast, and decides that the best way to find them is to appoint himself the resident psychiatrist. He becomes one of the most popular guys in school by doling out advice and, occasionally, medication, to the student body.

Life seems easy for picture-perfect couple Ivy and Theo: successful careers, a loving marriage, great kids. But beneath the façade of their supposed ideal life, a storm is brewing – as Theo's career nosedives while Ivy's own ambitions take off, a tinderbox of fierce competition and hidden resentment ignites.