An ex-Vietnam vet is forced to become a hit-man and gets caught in the middle of a conspiracy.

Django arrives in the town of Santa Anna at the behest of a man named Sanders who'd been trying to buy safe passage for his cargo from a Mexican bandit named El Santo. Django finds that Sanders has been killed and that his rival, a man named Thompson, is now trying to deal with El Santo. Django, after a brief involvement with a beautiful young widow named Linda -- who has information on a lost gold mine -- becomes entangled in this situation by agreeing to escort a shipment through El Santo's territory.

Sartana and Trinity set out on a grudging relationship hell bent for gold and comic brawls.