Two go-go dancers, Lulu and Peaches, are framed for the murder of their employer by the real killer, sleazy gangster Vinnie. Picking up waitress Darlene along the way, the three are involved in wild car chases with cops as they head south to cross the border into Mexico, where they unexpectedly encounter Vinnie in a fleabag Mexican motel.

A 19th century vampire stalks a more powerful vampire lord in his quest to gain revenge over the death of his mistress. In his search for the vampire lord in Eastern Europe he kills many of his servants and fellow vampires while cursing another to vampirism as well.

Still in the thrall of the evil vampire Radu, Michelle yearns to be taught the skills of the vampire. Meanwhile, her sister Becky tries to free her from his evil clutches, and this time, she's brought some help.

Continuing after the first "Subspecies", a woman who has just become a vampire tries to escape the evil vampire, Radu, who seeks her as his love interest. But she has taken the vampire family's bloodstone, and now Radu must find her to get it back. While her sister comes to Romania to save her soul. It might be too late....