A former mental patient's repressed anger reaches the boiling point, leading him to embark on a mission of revenge against the thugs who once subjected him to severe physical and mental trauma.

Finally released from prison, Elwood Blues is once again enlisted by Sister Mary Stigmata in her latest crusade to raise funds for a children's hospital. Hitting the road to re-unite the band and win the big prize at the New Orleans Battle of the Bands, Elwood is pursued cross-country by the cops.