Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.

Following Jigsaw's grisly demise, Detective Mark Hoffman is commended as a hero, but Agent Strahm is suspicious, and delves into Hoffman's past. Meanwhile, another group of people are put through a series of gruesome tests.

故事讲述了4岁时的玛蒂尔达就已经把家里的书读完了，但基本上都是杂志，因为她那个经商的爸爸和嗜赌的妈妈根本不读书，所以也想不到为异常聪明的女儿买书读。还是玛蒂尔达自己提出上学的要求，父母才把她送进康琴小学。校长特拉奇布尔小姐投铅球出身，哪个学生不听话，她就把孩子像铅球一样投出墙外。全校师生都生活在她的阴影之下，玛蒂尔达也不例外。虽然不如意事十之八九，但一年级老师汉妮小姐是小女孩心头的一缕阳光……