Ocho is accidentally captured by a drug trafficking cartel who use Chinese women to smuggle drugs into Japan by hiding it in their vaginas. She is tortured, and manages to escape, fighting both the male yakuzas and a gang of female thieves.

Sex & Fury chronicles Ocho's exploits as she searches for her father's killers, each identified by unique tattoos on their backs (a deer, a boar, and a butterfly). Along the way, she also crosses paths with Shonusuke, a radical set on murdering prominent politician Kurokawa and Christina, an American spy posing as a gambler.