In Sierra Negra, graverobbers Barraza and Mendoza steal the coffin of Count Karol de Lavud, before heading to a hospital. Barraza sees a medallion upon the coffin's opening and demands more money from Mendoza. Meanwhile, Marta González, recovering from traumatic events, works as a nurse with Dr. Saldívar. When Barraza removes the wooden stake in order to steal Lavud's medallion, the vampire returns to life and begins a crime spree, hunting down Marta to marry her.

A scientist experimenting with past lives finds a reincarnated Aztec who can lead him to lost treasure—and to a creature that should remain lost. (Composed of footage from two unrelated Mexican horror films, LA CASA DEL TERROR and LA MOMIA AZTECA, plus new American-made footage.)