In a whorehouse in Acapulco, lives Leonor, a young and beautiful woman who is awaiting to reunite with an old lover. Suddenly, the man reappears to take her away from her life of vice. But the debt owed by Leonor to the "Madame" of the house causes a series of conflicts.

After a group of violent lepers escapes from a sanitarium, - robbing several farms, residents of the town demand the the sheriff - take action. Meanwhile, a local criminal joins forces with the lepers - to commit even more robberies. As the disfigured madmen keep the - entire town indoors with its reign of terror, the sheriff has no - choice but to call on the only man who can help--legendary wrestling - superhero, Santo!

Masked luchador "Santo" fights against an evil doctor and his zombie army.