The film tells the story of a prop from the 1923 movie The Ten Commandments that was actually an authentic artifact from antiquity with cursed powers. In the modern day these resurface leading to murder and mayhem.

The Doom Patrol’s members each suffered horrible accidents that gave them superhuman abilities — but also left them scarred and disfigured. Traumatized and downtrodden, the team found purpose through The Chief, who brought them together to investigate the weirdest phenomena in existence — and to protect Earth from what they find.