On a flight transporting dangerous convicts, murderer Ryan Weaver manages to break free and cause complete chaos throughout the plane. As various people on board fall victim to Weaver, it is ultimately down to flight attendant Teri Halloran to keep the aircraft from crashing, with on-ground support from an air traffic controller. While Halloran struggles to pilot the plane, Weaver continues to terrorize the surviving members of the crew.

While heading to the town where his sister, Marci, lives, big-city banker Bill Campbell is robbed by a woman who takes everything he has, including his clothes and a business document worth millions of dollars. Bill eventually reunites with Marci, who is in a tizzy because she thinks their stepfather has been killed. While trying to determine if his sister is right, Bill must also get back his valuable paperwork.