London, England, on the eve of World War II. Guinevere Pettigrew, a strict governess who is unable to keep a job, is fired again. Lost in the hostile city, a series of fortunate circumstances lead her to meet Delysia LaFosse, a glamorous and dazzling American jazz singer whose life is a chaos ruled by indecision, a continuous battle between love and fame.

England, 1021: Born in a miserable mining town, Robert Cole swears to become a physician and vanquish disease and death. His harsh path of many years, a quest for knowledge besieged by countless challenges and sacrifices, leads him to the remote Isfahan, in Persia, where he meets Ibn Sina, the greatest healer of his time.