The film tells the story of two good friends who live together, Andrew, an agoraphobic travel agent who works from his home, and Dave, a loser who works in an office where he is treated with contempt. Just when it seems things can't get any worse for the two, the entire world outside of their house disappears and is replaced with an endless white void.

Olivier Assayas, Gus Van Sant, Wes Craven and Alfonso Cuaron are among the 20 distinguished directors who contribute to this collection of 18 stories, each exploring a different aspect of Parisian life. The colourful characters in this drama include a pair of mimes, a husband trying to chose between his wife and his lover, and a married man who turns to a prostitute for advice.

Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.

A group of strangers find themselves trapped in a maze-like prison. It soon becomes clear that each of them possesses the peculiar skills necessary to escape, if they don't wind up dead first.