In post-apocalyptic New York, three tribes of survivors (the Norms, the Mutates and the Upriver People) vie for the right to exist. When the treacherous Upriver People attack the Norms, kill their chief and take their people captive, two Norm refugee men must find a way to ally with the Mutates, who have previously kidnapped Norm women in an effort to reproduce healthy children, to rout the Uprivers, who also seek to kill off the Mutates.

A 17th-century Caribbean port rumored to have frequented by pirates rises from the ocean floor, where it came to rest after an earthquake many years before. A scientist wants to study it, some thugs want the treasure alleged to be stored there, a bunch of mutated giant crabs living there attack them all.

A young woman discovers she is the daughter of the infamous Dr. Jekyll, and begins to believe that she may also have a split personality, one of whom is a ruthless killer.