As their first year of high school looms ahead, best friends Julie, Hannah, Yancy and Farrah have one last summer sleepover. Little do they know they're about to embark on the adventure of a lifetime. Desperate to shed their nerdy status, they take part in a night-long scavenger hunt that pits them against their popular archrivals. Everything under the sun goes on -- from taking Yancy's father's car to sneaking into nightclubs!

When Erik Stifler realizes that he's the only Stifler family member who might graduate high school a virgin, he decides to live up to his legacy. After some well-meaning advice from Jim's dad, Erik's ready to take his chances at the annual and infamous Naked Mile race, where his devoted friends and some uninhibited sorority girls will create the most outrageous weekend ever.

College freshman Sydney White arrives at Southern Atlantic University, determined to pledge her late mother's sorority. Unfortunately, she finds that the sisterhood has changed since her parent's day. Banished to a condemned house, Sydney joins forces with seven outcasts to take over the student government and win equal rights for nerd and noted alike.