2150 A.D. The battle with the Festum, the silicon life-forms from distant outer space, had reached a new dimension. The North Polar Meir that was crushed during the First Azure Operation had dispersed its fragments all over the world. They all started activity on their own as independent Meirs. Most of the Meirs harbored hatred towards humanity and challenged a fight, however, a portion of the Festum chose coexistence with mankind. Amongst the crossfire, the Ryugujima island alone disappeared from the forefront of battle and continued its silence. The island had gained a means to converse with the Meir since their encounter with Misao Kurusu two years ago. The children of ALVISS had been searching for a way to understand the enemy as they prepared for battle. And now, once again, further evolution was about to befall the island. A girl that understands the language of the Festum, and a girl protected by a Festum. When the two meet, the doors to a new universe opens.

Kaede Honjou is invited by her friend Risa Shiramine to play a virtual reality MMO game with her. While Kaede doesn't dislike games, what she really, truly dislikes is being in pain. She creates a character named Maple, and decides to put all her points in VIT to minimize pain. As a result, she moves slowly, can't use magic, and even a rabbit can get the best of her. But as it turns out, she acquires a skill known as "Absolute Defense" as a result of her pumping points into VIT, as well as a "Counter Skill" that works against special moves. Now, with her ability to nullify all damage, she goes on adventures.

Thorfinn pursues a journey with his father's killer in order to take revenge and end his life in a duel as an honorable warrior and pay his father a homage.

Gabimaru reigns as the strongest and most ruthless assassin in his village. But now finds himself on death row—with only one way out: retrieve the Elixir of Life from a sinister island. Longing for freedom, he accepts the challenge. But with fellow convicts vying for the same prize and demonic beasts lurking, how will Gabimaru survive this harrowing quest?

Shouya Ishida starts bullying the new girl in class, Shouko Nishimiya, because she is deaf. But as the teasing continues, the rest of the class starts to turn on Shouya for his lack of compassion. When they leave elementary school, Shouko and Shouya do not speak to each other again... until an older, wiser Shouya, tormented by his past behaviour, decides he must see Shouko once more. He wants to atone for his sins, but is it already too late...?