Two identical twins, separated since infancy, meet after 30 years causing a series of mistaken identity and crisis for all involved.

The Stooges run a drug store and are about to have their lease taken away by Amos Flint, the mean old man who owns the place. When Flint kicks his wife out for being too old, the Stooges try to help her by inventing a formula that makes old people young. Their concoction turns the wife into a beautiful young woman, and Flint offers the boys the store for free if they'll transform him as well. They agree, but after he swallows the stuff he turns into an infant, and the boys leave on the run.

The stooges are private detectives looking for a missing millionaire. They wander around the millionaire's spooky mansion confronting various crooks and a dangerous dame. The stooges vanquish the crooks (Shemp uses his "trusty shovel") and find the missing man.

The fate of the planet in the hands of Larry, Moe and Curly Joe? That's exactly the situation the trio finds themselves in when they befriend a wacky scientist and must defend his secret invention from a pair of malevolent Martians. Sight gags, slapstick and plenty of nyuks abound as the Stooges bumble their way through an adventure of intergalactic proportions.

Rance Roden plans to kill off all the buffalo and thus cause the Indians to riot. After they destroy the US Cavalry, Rance and his gang will take over the West. Meanwhile, a Boston magazine gets wind of the buffalo slaughter and sends editor Kenneth Cabot and his associates to Casper, Wyoming to investigate.

The Stooges are painters and paperhangers and completely wreck a hapless couples home.

Shemp has to get married within seven hours in order to inherit $500,000. Now that's incentive! The bumbling threesome set to work right away with hilarious results.