Government agents Ted Everett and Tumbleweed are sent to Spearville, Texas, where the law agencies have failed to stop a series of bank robberies. Arriving incognito, they become involved with the gang, and end up being accused of murdering banker Bartlet Mellon. They escape a lynch mob and return with evidence that Mellon has faked his death, hoping to gain the insurance, and is also leading the gang under another name.

Attorney Wayne Fletcher and his secretary have an affair. When Wayne's wife is found smothered to death, he becomes the prime suspect. As the police investigate the murder, a psychic with questionable motives tries to contact the deceased woman. Soon, Wayne begins seeing visions of his dead wife, and other people involved with the case begin to be killed, one by one.

A seemingly charitable soup kitchen operator (who moonlights as a criminology professor) uses his Bowery mission as a front for his criminal gang. Police attempt to close in on the gang as they commit a series of robberies, murders and bizarre experiments on corpses.