The Powerpuff Girls is a animated television series about Blossom, Bubbles, and Buttercup, three kindergarten-aged girls with superpowers, as well as their "father", the brainy scientist Professor Utonium, who all live in the fictional city of Townsville, USA. The girls are frequently called upon by the town's childlike and naive mayor to help fight nearby criminals using their powers.

The adventures of Wander, an eternally-optimistic intergalactic traveler and constant do-gooder, and his quick-tempered but loyal steed and best friend, Sylvia. The friendliest face in outer space, Wander journeys across the galaxies to spread good cheer and to help anyone he can — much to his overly pragmatic stallion’s chagrin. Their fun-loving escapades often lead them to clash with the evil villain Lord Hater and his army of Watchdogs, who travel from planet to planet trying to make hate the order of the day. Together, the best friends travel through the cosmos, happening upon one freewheeling adventure after another and making new friends and foes.

Sometimes, imaginary friends get lost or kids simply outgrow them. That's why Madame Foster started Foster's Home for Imaginary Friends.