The Return of Sherlock Holmes was the first sound film to feature Sherlock Holmes.

A young model is set up with her own fashion business by a crooked financier, who sells worthless bonds.

Barry Brandon, a criminal lawyer, visits the night club of Denny Larkin, his primary client, with Betty Walker, a spoiled society girl. The police raid the club and Brandon pleads that the whole group is guilty, just to get even with Larkin for a rebuke. On the same night in court, Madge Carter is on trial for disorderly conduct, and Brandon volunteers to defend her, and proves the case against her if a frame-up. Finding that she is penniless, Brandon hires her as his secretary, and falls in love with her. Brandon is appointed district attorney and has ambitions of becoming the state governor. Having dinner at Betty's home, she maneuvers him, while he is drunk, into marrying her. Later, Madge is a witness when Larkin shoots down a fellow gangster. By threatening Brandon's life, he forces her to commit perjury at his trial, and say he fired in self-defense. Brandon, the prosecuting attorney (who has had his marriage to Betty annulled) knows she is lying but doesn't know why.

A mother wishes for the return of her dead son, a wish that is granted by the severed paw of a dead monkey.

Steve Morgan kills a man in a holdup and hitches a ride to Los Angeles with Fergie. At a gas station, they pick up two women. Encountering a roadblock, Morgan takes over and persuades the party to spend the night at an unoccupied beach house. The police close in as one by one, the others learn that Morgan is a killer.