After foiling Cruella DeVil's plot to make a fur coat with the puppies' skins, the Dearly Family (Roger and Anita Dearly, Nanny, Pongo, Perdita, their 15 birth puppies and 84 adopted puppies) move to a new farm home in the country. Join Pongo and Perdy's pups, brave Lucky, tubby Rolly and Cadpig the runt, together with their chicken friend Spot, as they defend their new home from Cruella DeVil (Anita's boss and now new neighbor), continually get in and out of trouble, sneak into Grutely, and have all sorts of crazy adventures around the farm. Also along for the fun is Tripod, Patch, Two-Tone, Wizzer, Dipstick, Mooch, and the rest of their barnyard friends.

Doug Funnie experiences common predicaments while attending school in his new hometown of Bluffington, Virginia.

Peanut, Jelly, and Baby Butter Otter live on a houseboat along with all of their friends. Whenever they get into a situation where they need to think, they perform "The Noodle Dance" until one of them gets an idea.