Molly McKay is a profoundly autistic twenty-something woman who has lived in an institution from a young age following her parents' death in a car accident. When the institution must close due to budget cuts, Molly is left in the care of her neurotypical, older brother, Buck McKay, an advertising executive and perennial bachelor. Buck forces her to undergo an experimental medical treatment, with unexpectedly drastic results.

Henry Hackett is the workaholic editor of a New York City tabloid. He loves his job, but the long hours and low pay are leading to discontent. Also, publisher Bernie White faces financial straits, and has hatchet-man Alicia Clark—Henry's nemesis—impose unpopular cutbacks.

Maverick cop Orin Boyd always brings down the domestic terrorists he tracks, but he ruffles feathers with his unorthodox techniques -- and soon finds himself reassigned to the toughest district in Detroit. When he discovers a group of detectives secretly operating a drug ring, Boyd joins forces with an unlikely ally -- gangster Latrell Walker -- to bring down the rotten cops.

Will Keane, a Manhattan restaurateur, is content with his playboy lifestyle until he meets Charlotte Fielding, a free-spirited young woman. Together the pair pursue a passionate affair that forces them both to reevaluate what they want out of life, even as fate threatens to steal away their future.

Elliot, a successful gynecologist, works at the same practice as his identical twin, Beverly. Elliot is attracted to many of his patients and has affairs with them. When he inevitably loses interest, he will give the woman over to Beverly, the meeker of the two, without the woman knowing the difference. Beverly falls hard for one of the patients, Claire, but when she inadvertently deceives him, he slips into a state of madness.

Restless and ready for an adventure, four suburban bikers leave the safety of their subdivision and head out on the open road. But complications ensue when they cross paths with an intimidating band of New Mexico bikers known as the Del Fuegos.

Forced to confront revelations about her past, paramedic Cassandra Webb forges a relationship with three young women destined for powerful futures...if they can all survive a deadly present.