The film follows the rise and fall of a family in Shanghai. Once wealthy and capitalist, the family unraveled during the Cultural Revolution in the 1960s and 1970s. Their home, once a French concession mansion, was converted into a multi-family dwelling.

In 1942, Henan Province was devastated by one of the most tragic famines in modern Chinese history, resulting in the deaths of at least three million men, women and children. Although the primary cause of the famine was a severe drought, it was exacerbated by locusts, windstorms, earthquakes, epidemic disease and the corruption of the ruling Kuomintang government.

医院外科专家安嘉和（冯远征 饰）是众人眼中一等一的好男人，他的事业一帆风顺，然而他却是一个具有家庭暴力倾向的丈夫。梅湘南（梅婷 饰）是他的第二任妻子，由于她有一段不堪回首的往事难以启齿，不料丈夫却最终起了疑心。家庭暴力的阴影开始在二人之间滋长。恰巧一次家庭暴力行为被对面楼的邻居叶斗拍了下来，为了不影响自己的前途，安嘉和向叶斗取回底片时，失手将其杀死。自此，安嘉和走上了不归路，不仅家庭暴力在迅速升级，为人也渐渐变得心狠手辣。梅湘南屡次想逃出安嘉和的魔爪，却令她在噩梦中越陷越深。安嘉和的弟弟安嘉睦（王学兵 饰）是一名人民警察，在与大哥和嫂子的相处中渐渐察觉出这个家庭不为人知的一面。而记者郑同（王劲松 饰）也奋力相助湘南，在交往中，他亦渐渐喜欢上了这个坚强的女子。