A father survives a plane crash in rural Appalachia, but becomes suspicious of the elderly couple who take him in to nurse him back to health with the ancient remedies.

The murder of a female GP in a rural playground in front of numerous witnesses draws a group of detectives into an ever-darkening mystery that takes them across Europe, aided by mysterious notes sent by the "Ghost Detective".

A mother and daughter move to a new town and find themselves living next door to a house where a young girl murdered her parents. When the daughter befriends the surviving son, she learns the story is far from over.