Saturday Night Live aired its thirty-fifth season during the 2009–2010 television season on NBC. This season began on September 26, 2009 and ended on May 15, 2010.

A total of 22 episodes were broadcast during the show's eight-month-long season, which included a two-week break in February due to the 2010 Winter Olympics. The season was accompanied by three prime-time episodes of Saturday Night Live Weekend Update Thursday and three prime-time SNL clip shows.

Prior to the start of the season, many cast changes occurred. Darrell Hammond, the last cast member from the 1990s, left the show after a record 14 seasons in the cast. Featured players Michaela Watkins and Casey Wilson were both let go from the show before the start of the season.

To fill their absence the show brought in two new featured players, Nasim Pedrad and Jenny Slate. Abby Elliott and Bobby Moynihan continued as featured players.

A notable moment of the season was when an internet campaign was created to get actress Betty White to host an episode of the show. The campaign was started in early 2010 on Facebook and the group was called "Betty White to Host SNL!" The campaign was successful, and White became the oldest person ever to host the show. For White's episode, Lorne Michaels brought back former cast members Rachel Dratch, Tina Fey, Ana Gasteyer, Amy Poehler, Maya Rudolph and Molly Shannon. The episode garnered its highest ratings in over a year. with a rating of 5.8 in the 18–49 rating, demographic and with 12.1 million viewers overall.

Hot dog Frank leads a group of supermarket products on a quest to discover the truth about their existence and what really happens when they become chosen to leave the grocery store.

Video game bad guy Ralph and fellow misfit Vanellope von Schweetz must risk it all by traveling to the World Wide Web in search of a replacement part to save Vanellope's video game, Sugar Rush. In way over their heads, Ralph and Vanellope rely on the citizens of the internet — the netizens — to help navigate their way, including an entrepreneur named Yesss, who is the head algorithm and the heart and soul of trend-making site BuzzzTube.

An orphan little girl befriends a benevolent giant who takes her to Giant Country, where they attempt to stop the man-eating giants that are invading the human world.

When 11-year-old Riley moves to a new city, her Emotions team up to help her through the transition. Joy, Fear, Anger, Disgust and Sadness work together, but when Joy and Sadness get lost, they must journey through unfamiliar places to get back home.

Agents J and K are back...in time. J has seen some inexplicable things in his 15 years with the Men in Black, but nothing, not even aliens, perplexes him as much as his wry, reticent partner. But when K's life and the fate of the planet are put at stake, Agent J will have to travel back in time to put things right. J discovers that there are secrets to the universe that K never told him - secrets that will reveal themselves as he teams up with the young Agent K to save his partner, the agency, and the future of humankind.

An island populated entirely by happy, flightless birds or almost entirely. In this paradise, Red, a bird with a temper problem, speedy Chuck, and the volatile Bomb have always been outsiders. But when the island is visited by mysterious green piggies, it’s up to these unlikely outcasts to figure out what the pigs are up to.

A listless hitman is enthralled by theatre acting and becomes eager to leave his old life behind in pursuit of a new career.

27 years after overcoming the malevolent supernatural entity Pennywise, the former members of the Losers' Club, who have grown up and moved away from Derry, are brought back together by a devastating phone call.

Times are changing for Manny the moody mammoth, Sid the motor mouthed sloth and Diego the crafty saber-toothed tiger. Life heats up for our heroes when they meet some new and none-too-friendly neighbors – the mighty dinosaurs.