Mary is a good Christian girl who goes to a good Christian high school where she has good Christian friends and a perfect Christian boyfriend. Her life seems perfect, until the day that she finds out that her boyfriend may be gay — and that she’s pregnant.

4400 centers on the return of 4400 people who, previously presumed dead or reported missing, reappear on Earth. Though they have not aged physically, some of them seem to have deeper alterations ranging from superhuman strength to an unexplained healing touch. A government agency is formed to track the 4400 people after one of them commits a murder.