In eighteenth-dynasty Egypt, Sinuhe, a poor orphan, becomes a brilliant physician and with his friend Horemheb is appointed to the service of the new Pharoah. Sinuhe's personal triumphs and tragedies are played against the larger canvas of the turbulent events of the 18th dynasty. As Sinuhe is drawn into court intrigues he learns the answers to the questions he has sought since his birth.

Drunk and disillusioned Roman, Marcellus Gallio, wins Jesus' robe in a dice game after the crucifixion. Marcellus has never been a man of faith like his slave, Demetrius, but when Demetrius escapes with the robe, Marcellus experiences disturbing visions and feels guilty for his actions. Convinced that destroying the robe will cure him, Marcellus sets out to find Demetrius — and discovers his Christian faith along the way.