Rally Vincent and Minnie May Hopkins are just a pair of gun shop owners who do a bit of bounty hunting to make ends meet when a Bureau of Alcohol, Tobacco, Firearms agent comes to them. Using the threat of arresting them for their lack of a retail license for their merchandise and the resulting unpaid taxes, he forces them to agree to cooperate in a sting to break a gun running ring. They have an initial success, but that brings new problems as the ring's leader brings in a merciless assassin to eliminate these new enemies. It will take all their skill, allies and some luck to come out this crisis alive.

The adventures of Patty Rabbit and Bobby Bear, who live in the small utopian city of Maple Town.

A story set in the mid-1800's about a young doctor who has been trained in Western-style medicine and a young samurai who is trying to live up to the old traditions of his class and culture. The story is actually based upon real people - the doctor, Ryo-an, was Tezuka's great grandfather.

The manga series was adapted to anime by Madhouse Studios and premiered in Japan on NTV on April 4, 2000.

During the Second Year of Ansei (1855) in Edo's Koishigawa are two young men, Manjiro Ibutani and Ryoan Tezuka. Ibutani is a low-ranking samurai who is a gifted swordsman and has a straightforward and strong sense of justice. Tezuka has a more carefree attitude. He has an eye for the ladies, but he is passionate about becoming a doctor. The two opposite characters come of age during the backdrop of the turbulent end of the Tokugawa Period (1600-1868 CE).