In ancient Rome, bathhouse architect Lucius (Hiroshi Abe) becomes famous with designing the original "thermae" (bathhouse). He receives an order to build a thermae in the colosseum to help gladiators recover from their wounds, but faces difficulties. Thus, Lucius travels again to modern day Japan through the time slip. He meets Manami (Aya Ueto) again, who is now a reporter for a magazine which covers bathroom. With the help of the flat face Japanese tribe, Lucius again designs a new thermae. Meanwhile, Emperor Hadrian (Masachika Ichimura) wants to keep the peace with the thermae, but the Senate wants to extend the land by using force. Emperor Hadrian and the Senate now have a confrontation and Rome becomes divided.

The story follows a Roman architect named Lucius, who is having trouble coming up with ideas. One day, he discovers a hidden tunnel underneath a spa that leads him to a modern Japanese bath house. Inspired by the innovations found there, he creates his own spa, Roma Thermae, bringing in the modern ideas to his time.

为了更专注自己的音乐事业，千秋真一（玉木宏 饰）向野田惠（上野树里 饰）提出分居的请求，浪漫之都巴黎，这对情侣两地相隔。当然野田并不会感到特别无聊，奥山真澄（小出惠介 饰）和峰龙太郎（瑛太 饰）的造访为她带来诸多的乐趣。原来每三年一度针对小提琴和钢琴的坎托纳国际竞演会召开在即，峰特意来给分别多年的恋人三木清良（水川あさみ 饰）加油打气。观看演出时，当拉威尔的G大调钢琴协奏曲响起时，野田深受触动，遂决定报名参赛，却被教授拒绝。与此同时，当听说复归后的孙蕊（山田优 饰）邀请千秋共演时心情更是跌落谷底。为了帮她重整旗鼓，千秋带领野田展开连番特训……
本片根据二之宫知子的原著漫画改编。

The smallest protagonist in film history - a human cell! There are a staggering 37 trillion cells in the human body. Red blood cells that carry oxygen, white blood cells that fight bacteria, and countless other cells work tirelessly day and night to protect your health and life. The film will also focus on daughter and father, Niko and Shigeru as they both live different lifestyles, and as their lively days go on, pathogens start to sneak up on their bodies. The most epic battle in the history of human cells, with the future of Niko and Shigeru at stake, is about to begin!

With the help of an online community, a nerdy and socially awkward man gathers the courage to start dating an attractive lady he met on a train.