Yataro Tanigawa, a one-eyed hired assassin, impresses yakuza boss Gomyo Kiyoemon with his skill. Gomyo hires Tanigawa as his bodyguard, or yojimbo, to protect him during an inter-clan conflict. Tanigawa quickly rises in stature in the clan, but finds his boss's enemies almost overwhelming.

After surviving the slaughter of many Christians 350 years ago, a samurai denounces God for ignoring the pleas of believers. He sells his soul to Satan and receives the power to resurrect the dead to join him in a murderous rampage.