John Leguizamo's semi-falsified, one-man stand-up performance as...himself. This is his autobiographical story, about his life growing up, and his journey to try to be accepted by his father. We see this story through a bizarre myriad of characters and situations, which include the eccentric Uncle Sanny, the Fat Boy Called Bitch (John's little brother, Poochie), his mom, his evil grandmothers, and Lee Stratsberg, not to mention a brief appearance by Cantinflas as God.

Fast-talking Latino con artist Pestario "Pest" Vargas is the target of Scottish mobsters to whom he owes a considerable debt. Willing to do anything to raise money and avoid severe injury or death, Vargas agrees to a very unusual job -- he will be transported to a remote island and hunted by Gustav Shank, a racist German executive. If he can survive a full day and night, Vargas gets $50,000 and will be set free. Is he wily enough to elude Shank?