After being abducted by Katarina Rostova, Raymond "Red" Reddington finds himself alone in hostile territory, unsure of who, if anyone, he can trust. Surrounded by old enemies and new allies, Red must stay one step ahead of the Blacklist's most dangerous criminal, who will stop at nothing to unearth the very truth Red wants no one to know about. To find it, Katarina will insinuate herself into the life of Elizabeth Keen, who has finally reunited with her daughter Agnes. Katarina’s presence will bring danger to Liz’s doorstep and forever alter her relationship with Red.

Following the startling revelation that Raymond "Red" Reddington isn't who he says he is, Elizabeth Keen is torn between the relationship she's developed with the man assumed to be her father and her desire to get to the bottom of years of secrets and lies. Meanwhile, Red leads Liz and the FBI to some of the most strange and dangerous criminals yet, growing his empire and eliminating rivals in the process. All throughout, Liz and Red engage in an uneasy cat-and-mouse game in which lines will be crossed and the truth will be revealed.

Feeling surprisingly unencumbered, Raymond Reddington is back, and in the process of rebuilding his criminal empire. His lust for life is ever-present as he lays the foundation for this new enterprise - one that he'll design with Elizabeth Keen by his side. Living with the reality that Red is her father, Liz finds herself torn between her role as an FBI agent and the temptation to act on her more criminal instincts. In a world where the search for Blacklisters has become a family trade, Red will undoubtedly reclaim his moniker as the “Concierge of Crime.”

A mysterious man claiming to be Liz’s real father targets her, but first she must resolve the mystery of her lost childhood and reconcile her true identity with the elusive memories corrupted by Reddington. Without the truth, every day holds more danger for herself, her baby and her husband Tom. Meanwhile, the Task Force reels from Liz’s resurrection and friendships are fractured. Betrayed by those closest to him, Reddington’s specific moral code demands justice, all the while battling an army of new and unexpected blacklisters.

A recently paroled Piper tries to get back on her feet while life in Litchfield, as corrupt as ever, goes on without her.

The power dynamics at Litchfield shift dramatically as the inmates react to a tragedy in an explosive new season.

New faces and old resentments make for a potentially volatile blend, especially now that Litchfield is a for-profit business.

New business interests, spiritual movements and parental problems upend lives and ignite power struggles among Litchfield's residents and guards.

Piper must trade her comfortable New York life for an orange prison jumpsuit when her decade-old relationship with a drug runner catches up with her.

Shocking revelations and new arrivals shake up the lives and relationships of Litchfield's prisoners.