A group of friends race their high-powered cars up and down a dangerous and deadly mountain road known as Mulholland Drive to see who can claim the title of "King of the Hill."

A man goes blind when remembering his lost girlfriend, but the doctors can't find anything wrong with his eyes. They fit him with an experimental device which allows him to see with the aid of a computer interface and brain electrodes. Meanwhile, a taxi driver is taking young women up to their apartments, giving them gas, and performing a little fatal amateur surgery on them. Their paths inevitably converge, and the blind man must try to stop the psychopath.