Season one begins the story of Dr. Ephraim Goodweather, the head of the CDC Canary Team in New York City. He and his team are called upon to investigate a viral outbreak with hallmarks of an ancient and evil strain of vampirism. As the strain spreads, Eph and his team wage war for the fate of humanity itself.

The transformation has begun in season two. New York City is falling to an evil epidemic and no one is coming to its rescue. Its citizens must fight or die. Now Eph and Dr. Martinez concentrate on creating a biological weapon, while Setrakian searches for an ancient book he hopes will reveal the strigoi's history...and possibly a way to kill them.

New York City is a battleground as humans fight for survival against the vampire apocalypse in season three. Though our heroes achieve small victories, they are not winning the war. Beset by personal conflicts – betrayal, disappointment, paranoia – the group splinters as the Master closes in on executing an irreversible transformation of the world.

As the final season begins, nine months have passed. The world has fallen into darkness, and the strigoi are in control. The Master and his minions have created an unsettling alliance in “The Partnership.” The majority of humans are now working for the strigoi, operating with a single understanding – collaborate or die. In the face of annihilation…do our heroes have what it takes to save humankind?