A ghostwriter finds himself romantically involved with his current wife, a married woman and his long-vanished wife.

Bored with day-to-day life in New York City and neglected by her husband, a young wife and mother slips into increasingly outrageous fantasies: her mother breaking into the apartment, an explorer's demonstration of tribal fertility music at a party causing strange transformations, and joining terrorists to plant explosives in the Statue of Liberty.

Stingo, a young writer, moves to Brooklyn in 1947 to begin work on his first novel. As he becomes friendly with Sophie and her lover Nathan, he learns that she is a Holocaust survivor. Flashbacks reveal her harrowing story, from pre-war prosperity to Auschwitz. In the present, Sophie and Nathan's relationship increasingly unravels as Stingo grows closer to Sophie and Nathan's fragile mental state becomes ever more apparent.