Lawrence Talbot, an American man on a visit to Victorian London to make amends with his estranged father, gets bitten by a werewolf and, after a moonlight transformation, leaves him with a savage hunger for flesh.

Mike Sullivan works as a hit man for crime boss John Rooney. Sullivan views Rooney as a father figure, however after his son is witness to a killing, Mike Sullivan finds himself on the run in attempt to save the life of his son and at the same time looking for revenge on those who wronged him.

The story of the Cuban Missile Crisis in 1962—the nuclear standoff with the USSR sparked by the discovery by the Americans of missile bases established on the Soviet-allied island of Cuba.